Investigating the role of caveolin in cell processes and diseases
Official title: Biophysical Studies of Caveolin
Funded at Lehigh University · NIH-10577560 · Data updated 2026-11-12
This study is looking at a special part of our cells called caveolae and a protein called caveolin that helps them work properly; by understanding how caveolin functions and what happens when it doesn’t, researchers hope to learn more about its role in health issues like cancer and heart problems.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lehigh University NIH-funded |
| Lab location | 1 site (Bethlehem, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $73,873 |
| NIH project number | 3R15GM141606-01S1 |
| Project ID | NIH-10577560 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to caveolin dysfunction, such as certain cancers or heart diseases.
✕Less likely to help
Patients with conditions unrelated to caveolin or those not experiencing any cellular dysfunction may not benefit from this research.
What this research studies
This research focuses on caveolae, specialized structures in cell membranes that are crucial for various cellular functions such as sensing mechanical changes, transporting substances into cells, and transmitting signals. The study examines caveolin, a key protein in these structures, to understand how its shape and interactions affect its function and how abnormalities in caveolin can lead to diseases like cancer and heart disorders. Using advanced techniques like fluorescence and nuclear magnetic resonance spectroscopy, researchers aim to clarify the structure and behavior of caveolin in the cell membrane, which could provide insights into its role in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of diseases associated with caveolin, potentially guiding the development of targeted therapies.
How similar studies have gone: While caveolin has been studied in various contexts, this specific investigation into its structural properties and implications for disease is relatively novel.
Where this research is happening
-
Lehigh University
Bethlehem, United States Active
Researchers
- Principal investigator: Glover, Kerney Jebrell — Lehigh University
- Study coordinator: Glover, Kerney Jebrell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.