Investigating the role of caveolin in cell processes and diseases
Biophysical Studies of Caveolin
['FUNDING_R15'] · LEHIGH UNIVERSITY · NIH-10198303
This study is looking at tiny structures in our cells called caveolae and a special protein called caveolin that helps them work properly, with the goal of understanding how changes in caveolin might be connected to diseases like cancer and heart problems, which could help us find new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LEHIGH UNIVERSITY (nih funded) |
| Locations | 1 site (BETHLEHEM, UNITED STATES) |
| Trial ID | NIH-10198303 on ClinicalTrials.gov |
What this research studies
This research focuses on caveolae, specialized structures in cell membranes that are crucial for various cellular functions such as sensing mechanical changes, transporting substances into cells, and transmitting signals. The study aims to understand the structure and behavior of caveolin, a key protein in these structures, using advanced techniques like fluorescence spectroscopy and nuclear magnetic resonance. By examining how caveolin functions and its potential mutations, the research seeks to uncover its links to diseases like cancer and heart conditions, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to caveolin dysfunction, such as certain types of cancer or heart diseases.
Not a fit: Patients without any known caveolin-related disorders or those not affected by the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into the mechanisms of diseases associated with caveolin, potentially leading to new treatments for cancer and other serious conditions.
How similar studies have performed: While caveolin has been studied in various contexts, this specific investigation into its structural properties and implications for disease is relatively novel.
Where this research is happening
BETHLEHEM, UNITED STATES
- LEHIGH UNIVERSITY — BETHLEHEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GLOVER, KERNEY JEBRELL — LEHIGH UNIVERSITY
- Study coordinator: GLOVER, KERNEY JEBRELL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer