Investigating the role of Cav1.2 calcium channels in bladder function and disorders
Official title: Cav1.2 in bladder physiology and pathology
Funded at Beth Israel Deaconess Medical Center · NIH-11059922 · Data updated 2026-11-12
This study is looking at how certain medications, like nifedipine, can help improve bladder function and relieve urinary problems for people dealing with conditions like ketamine cystitis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 21, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $486,870 |
| NIH project number | 5R01DK135672-02 |
| Project ID | NIH-11059922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing lower urinary tract symptoms or bladder pain syndrome.
✕Less likely to help
Patients with bladder conditions unrelated to Cav1.2 function may not benefit from this research.
What this research studies
This research focuses on the Cav1.2 calcium channel, which plays a crucial role in bladder smooth muscle function. The study aims to understand how Cav1.2 antagonists, like nifedipine, affect bladder contractions and urinary symptoms. By exploring the mechanisms behind bladder dysfunction, including conditions like ketamine cystitis, the research seeks to identify new therapeutic approaches for patients suffering from lower urinary tract symptoms. The methodology includes animal models to assess the effects of various compounds on bladder function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with bladder dysfunction and lower urinary tract symptoms.
How similar studies have gone: Previous research has shown mixed results with calcium channel blockers in bladder treatment, making this investigation both relevant and necessary.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Yu, Weiqun — Beth Israel Deaconess Medical Center
- Study coordinator: Yu, Weiqun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.