Investigating the role of cardiac exosomes in heart injury from reduced blood flow
Cardiac Exosomes in myocardial Ischemic injury
This study is looking at tiny particles released by heart cells to see how they might affect heart damage when blood flow is reduced, and it's for patients having heart surgery to help find new ways to treat heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10984767 on NIH RePORTER |
What this research studies
This research focuses on understanding how cardiac exosomes, which are small vesicles released by heart cells, contribute to the injury caused by reduced blood flow during ischemic heart disease. By analyzing samples from patients undergoing cardiac surgery, the study aims to uncover the biological processes involved in heart cell communication and the potential role of noncoding RNAs in these processes. The research utilizes advanced techniques to examine the genetic and molecular changes in heart cells during ischemia, providing insights into new therapeutic approaches and biomarkers for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing cardiac surgery who experience myocardial ischemia.
Not a fit: Patients with stable ischemic heart disease who are not undergoing surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments and diagnostic tools for patients suffering from ischemic heart disease.
How similar studies have performed: Previous research has shown promise in using extracellular vesicles as biomarkers and therapeutic agents in various conditions, indicating a potential for success in this novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Muehlschlegel, Jochen Daniel — Johns Hopkins University
- Study coordinator: Muehlschlegel, Jochen Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.