Investigating the role of calcium in Alzheimer's Disease
Calcium and the Pathophysiology of Neurodegenerative Disorders
This study is looking at how calcium levels in brain cells might play a role in Alzheimer's Disease, and it's for anyone interested in understanding how stress could affect memory and thinking; the researchers hope to find ways to fix calcium problems to help improve brain function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10611794 on NIH RePORTER |
What this research studies
This research explores how calcium levels in neurons may contribute to the development of Alzheimer's Disease (AD). The team hypothesizes that stress-related factors lead to leaks in calcium release channels, which could result in cognitive decline and AD pathology. By studying these mechanisms in a mouse model, they aim to identify potential therapeutic targets, such as stabilizing calcium channels to improve cognitive function. The research involves both pharmacological interventions and genetic modifications to better understand the relationship between calcium handling and AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's Disease.
Not a fit: Patients with non-neurodegenerative cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in patients with Alzheimer's Disease.
How similar studies have performed: Previous research has shown promising results using similar approaches to stabilize calcium channels in models of cognitive dysfunction.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Marks, Andrew Robert — Columbia University Health Sciences
- Study coordinator: Marks, Andrew Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.