Investigating the role of brain endothelial cilia in maintaining blood vessel stability
Basolateral brain endothelial cilia and its role in promoting vascular stability
This study is looking at tiny hair-like structures on the sides of blood vessels in the brain to see how they help brain cells communicate and keep blood vessels healthy, which could be important for people with conditions affecting brain blood flow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11119191 on NIH RePORTER |
What this research studies
This research explores the presence of cilia on the basolateral side of brain blood vessels and their potential role in communication with surrounding cells to maintain vascular stability. The study hypothesizes that these cilia are crucial for signaling between endothelial cells and pericytes, which are important for the health of blood vessels. By examining the interactions at the cellular level, the research aims to understand how these signals contribute to the stability of the vascular system in the brain. The methodology includes evaluating specific signaling molecules and their effects on endothelial cell behavior in a controlled laboratory setting.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting brain blood vessels or those at risk for vascular instability.
Not a fit: Patients with conditions unrelated to vascular stability or those without brain vascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating vascular-related diseases in the brain.
How similar studies have performed: While the specific focus on basolateral cilia in brain endothelial cells is novel, similar research has shown promising results in understanding vascular stability through cellular communication.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Ramchandran, Ramani — Medical College of Wisconsin
- Study coordinator: Ramchandran, Ramani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.