Investigating the role of BMP3 in pulmonary hypertension
Paracrine Action of BMP3 in Pulmonary Hypertension
This study is looking at how a protein called BMP3 affects pulmonary arterial hypertension (PAH), a serious lung condition, by checking its levels in patients and animals, which could help find new ways to treat PAH.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-10895395 on NIH RePORTER |
What this research studies
This research focuses on understanding how BMP3, a protein involved in cell signaling, affects pulmonary arterial hypertension (PAH), a serious condition that can lead to heart failure. The researchers will conduct experiments to measure BMP3 levels in patients and animal models with PAH, exploring how this protein influences the function of specific lung cells. By examining the interactions between different cell types, the study aims to uncover new insights into the mechanisms of PAH and identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with pulmonary arterial hypertension.
Not a fit: Patients with other forms of pulmonary hypertension or those without a diagnosis of pulmonary arterial hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promising results in understanding the BMP signaling pathway in pulmonary hypertension, suggesting that this approach may yield valuable insights.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Sassi, Yassine — Virginia Polytechnic Inst and St Univ
- Study coordinator: Sassi, Yassine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.