Investigating the role of BIN1 in Alzheimer's disease
Official title: BIN1-interactome in Alzheimer's disease pathophysiology
Funded at University of South Florida · NIH-10848245 · Data updated 2026-11-12
This study is looking at how a protein called BIN1, which is linked to Alzheimer's disease, affects brain health in older adults, and it aims to find out how different forms of this protein work with others in the brain to help us understand the disease better and possibly find new ways to treat it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 14, 2023 |
| Project end | August 13, 2025 |
| Funding year | 2024 |
| Award (this year) | $39,373 |
| NIH project number | 5F31AG082397-02 |
| Project ID | NIH-10848245 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those aged 65 and older, who may be at risk for Alzheimer's disease.
✕Less likely to help
Patients who are younger than 65 or do not have any risk factors for Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding how the BIN1 protein, a significant genetic risk factor for Alzheimer's disease (AD), affects brain function in older adults. The study aims to identify the various forms of BIN1 present in the brain and how they interact with other proteins to influence neuronal health. By using advanced techniques like proximity biotin ligase and mass spectrometry, researchers will explore the cellular mechanisms that may contribute to the development of AD. This could provide insights into the biological processes that lead to the disease, potentially paving the way for new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of Alzheimer's disease and inform the development of targeted treatments.
How similar studies have gone: Previous research has shown promise in understanding genetic risk factors for Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Mcmillan, Joseph — University of South Florida
- Study coordinator: Mcmillan, Joseph
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.