Investigating the role of BIN1 in Alzheimer's disease
BIN1-interactome in Alzheimer's disease pathophysiology
This study is looking at how a protein called BIN1, which is linked to Alzheimer's disease, affects brain health in older adults, and it aims to find out how different forms of this protein work with others in the brain to help us understand the disease better and possibly find new ways to treat it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10848245 on NIH RePORTER |
What this research studies
This research focuses on understanding how the BIN1 protein, a significant genetic risk factor for Alzheimer's disease (AD), affects brain function in older adults. The study aims to identify the various forms of BIN1 present in the brain and how they interact with other proteins to influence neuronal health. By using advanced techniques like proximity biotin ligase and mass spectrometry, researchers will explore the cellular mechanisms that may contribute to the development of AD. This could provide insights into the biological processes that lead to the disease, potentially paving the way for new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and older, who may be at risk for Alzheimer's disease.
Not a fit: Patients who are younger than 65 or do not have any risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of Alzheimer's disease and inform the development of targeted treatments.
How similar studies have performed: Previous research has shown promise in understanding genetic risk factors for Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Mcmillan, Joseph — University of South Florida
- Study coordinator: Mcmillan, Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.