Investigating the role of BCL6 in chronic lymphocytic leukemia
Study Pro-Oncogenic Role of BCL6 in CLL Tumorigenesis
This study is looking at how a protein called BCL6 affects chronic lymphocytic leukemia (CLL) to help us understand why the cancer grows and resists treatment, with the hope of finding better ways to manage the disease for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10661814 on NIH RePORTER |
What this research studies
This research focuses on chronic lymphocytic leukemia (CLL), a type of cancer affecting B-cells, to understand the molecular mechanisms that contribute to its development and resistance to treatment. The study examines the role of a protein called BCL6, which may influence cancer cell survival and proliferation. By analyzing genetic and protein expressions in CLL cells, the researchers aim to uncover how BCL6 contributes to the disease's progression and treatment resistance. This could lead to new therapeutic strategies for managing CLL more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic lymphocytic leukemia, particularly those who are newly diagnosed or experiencing treatment resistance.
Not a fit: Patients with other types of leukemia or those who do not have chronic lymphocytic leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with chronic lymphocytic leukemia.
How similar studies have performed: Previous research has shown promising results in understanding the roles of various proteins in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Ghosh, Asish Kumar — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Ghosh, Asish Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.