Investigating the role of BACH1 in regulating inflammation in immune cells.
Official title: BACH1 as a novel pioneer repressor in macrophages: impact on homeostasis and inflammation
Funded at Johns Hopkins University · NIH-10954329 · Data updated 2026-11-12
This study is looking at how a protein called BACH1 affects immune cells that help control inflammation, which could lead to new ways to treat inflammatory diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $550,706 |
| NIH project number | 1R01AI185363-01 |
| Project ID | NIH-10954329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inflammatory conditions or diseases where macrophage function is disrupted.
✕Less likely to help
Patients with non-inflammatory conditions or those not involving macrophage activity may not receive any benefit from this research.
What this research studies
This research focuses on understanding how a protein called BACH1 influences the behavior of macrophages, which are crucial immune cells involved in inflammation. By examining the mechanisms of transcriptional regulation, the study aims to uncover how BACH1 acts as a repressor that shapes the macrophage epigenome, impacting their differentiation and response to inflammation. The research employs advanced techniques like ATAC sequencing to analyze chromatin accessibility and gene expression patterns in macrophages. Patients may benefit from insights gained into inflammatory diseases and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating inflammatory diseases by targeting the mechanisms regulated by BACH1.
How similar studies have gone: Other research has shown promising results in understanding transcriptional regulation in immune cells, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Nagy, Laszlo — Johns Hopkins University
- Study coordinator: Nagy, Laszlo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.