Investigating the role of B lymphocytes in heart inflammation and injury
Myocardial-associated B lymphocytes and inflammatory injury
This study is looking at how certain immune cells called B cells affect inflammation and heart damage in people with heart failure, and it hopes to find ways to improve heart function by changing how these B cells work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11011338 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific B cells contribute to inflammation and heart damage, particularly in the context of heart failure. The study aims to explore the behavior of these B cells in the heart and their interactions with other immune cells during injury. By using animal models, researchers will investigate how manipulating these B cells can improve heart function after damage. This could lead to new treatments that target B cells to reduce inflammation and enhance recovery in heart failure patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from heart failure or related cardiac conditions.
Not a fit: Patients with non-cardiac related health issues or those without heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve heart function and recovery in patients with heart failure.
How similar studies have performed: Other research has shown promising results in targeting B cells for immunomodulatory therapies, suggesting potential success for this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Adamo, Luigi — Johns Hopkins University
- Study coordinator: Adamo, Luigi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.