Investigating the role of AURKA in stomach cancer development
Intercepting novel functions of AURKA in gastric tumorigenesis
This study is looking at how a protein called AURKA affects the growth of stomach cancer in people who have a Helicobacter pylori infection, with the goal of finding new ways to improve treatment and help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10899451 on NIH RePORTER |
What this research studies
This research focuses on understanding how the AURKA protein contributes to the development of gastric cancer, particularly in patients infected with Helicobacter pylori, a known carcinogen. The study aims to explore the molecular mechanisms by which AURKA promotes tumor growth and resistance to treatment. By examining the interactions between AURKA and other critical genes, the research seeks to identify potential therapeutic targets that could improve treatment outcomes for gastric cancer patients. The findings could lead to new strategies for early detection and intervention in gastric cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with gastric cancer, particularly those with a history of Helicobacter pylori infection.
Not a fit: Patients with gastric cancer who are not infected with Helicobacter pylori or those with early-stage disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for gastric cancer, improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in targeting AURKA in other cancer types, suggesting potential for success in gastric cancer as well.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: El-Rifai, Wael — University of Miami School of Medicine
- Study coordinator: El-Rifai, Wael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.