Investigating the role of ATP13A2 in age-related neurodegenerative diseases
ATP13A2 and Susceptibility to Neurodegeneration
This study is looking at how a specific gene called ATP13A2 might influence the chances of developing neurodegenerative diseases like Parkinson's as we get older, with the hope of finding new ways to detect and prevent these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeast Ohio Medical University NIH-funded |
| Lab location | 1 site (Rootstown, United States) |
| Project ID | NIH-10881743 on NIH RePORTER |
What this research studies
This research focuses on understanding how the ATPase ATP13A2 contributes to the risk of developing neurodegenerative diseases as people age. It aims to explore the interactions between genetic factors, environmental exposures, and the aging process that may lead to conditions like Parkinson's disease. By studying how ATP13A2 affects mitochondrial maintenance and neuronal vulnerability to toxins, the research seeks to identify potential pathways for early detection and prevention of neurodegeneration. Patients may benefit from insights that could lead to new treatment strategies or preventive measures.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for age-related neurodegenerative diseases, particularly those with a family history of such conditions.
Not a fit: Patients who do not have any genetic predisposition or environmental risk factors for neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for early detection and prevention of neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic factors in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Rootstown, United States
- Northeast Ohio Medical University — Rootstown, United States (Active)
Researchers
- Principal investigator: Fleming, Sheila — Northeast Ohio Medical University
- Study coordinator: Fleming, Sheila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.