Investigating the role of ATP13A2 in age-related neurodegenerative diseases
Official title: ATP13A2 and Susceptibility to Neurodegeneration
Funded at Northeast Ohio Medical University · NIH-10881743 · Data updated 2026-11-12
This study is looking at how a specific gene called ATP13A2 might influence the chances of developing neurodegenerative diseases like Parkinson's as we get older, with the hope of finding new ways to detect and prevent these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeast Ohio Medical University NIH-funded |
| Lab location | 1 site (Rootstown, United States) |
| Project start | September 28, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $329,485 |
| NIH project number | 5R01ES031124-05 |
| Project ID | NIH-10881743 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for age-related neurodegenerative diseases, particularly those with a family history of such conditions.
✕Less likely to help
Patients who do not have any genetic predisposition or environmental risk factors for neurodegenerative diseases may not benefit from this research.
What this research studies
This research focuses on understanding how the ATPase ATP13A2 contributes to the risk of developing neurodegenerative diseases as people age. It aims to explore the interactions between genetic factors, environmental exposures, and the aging process that may lead to conditions like Parkinson's disease. By studying how ATP13A2 affects mitochondrial maintenance and neuronal vulnerability to toxins, the research seeks to identify potential pathways for early detection and prevention of neurodegeneration. Patients may benefit from insights that could lead to new treatment strategies or preventive measures.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for early detection and prevention of neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of genetic factors in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northeast Ohio Medical University
Rootstown, United States Active
Researchers
- Principal investigator: Fleming, Sheila — Northeast Ohio Medical University
- Study coordinator: Fleming, Sheila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.