Investigating the role of astrocytic end-feet in vascular contributions to cognitive impairment and dementia.
Project 1 - Astrocytic end-feet and VCID
This study is looking at how problems with blood vessels in the brain might lead to memory and thinking issues in people with Alzheimer's and similar conditions, using mice to see how certain proteins affect brain health and function.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10897077 on NIH RePORTER |
What this research studies
This research focuses on understanding how vascular issues contribute to cognitive impairment and dementia, particularly in patients with Alzheimer's disease and related dementias. The study examines astrocytic end-feet, which are critical for maintaining brain health, and how their degeneration affects neuronal function. By using a mouse model, researchers will manipulate specific proteins to observe their effects on brain health and cognitive function. This approach aims to uncover the mechanisms behind neurodegeneration and identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing vascular contributions to their cognitive impairment.
Not a fit: Patients with non-vascular forms of dementia or those without any form of cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and slow the progression of dementia in patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of astrocytes in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Wilcock, Donna M — University of Kentucky
- Study coordinator: Wilcock, Donna M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.