Investigating the role of astrocytes in inflammation related to Alzheimer's and vascular cognitive impairment.
Inflammatory contributions of astrocytic RelA in comorbid VCID/AD
This study is looking at how inflammation in the brain, especially from certain brain cells called astrocytes, affects Alzheimer's disease and thinking problems, with the hope of finding new ways to help people with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10609965 on NIH RePORTER |
What this research studies
This research explores how inflammation in the brain, particularly through a type of cell called astrocytes, contributes to the development and progression of Alzheimer's disease and vascular contributions to cognitive impairment. By studying both human and animal models, the research aims to understand the mechanisms behind neuroinflammation and its impact on cognitive function. The focus is on a specific signaling pathway (RelA) in astrocytes that may drive these inflammatory processes, potentially leading to new insights into treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing vascular cognitive impairment.
Not a fit: Patients with cognitive impairments not related to Alzheimer's disease or vascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for Alzheimer's disease and related cognitive impairments by targeting inflammatory processes in the brain.
How similar studies have performed: Previous research has shown promising results in understanding neuroinflammation's role in cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Morganti, Josh — University of Kentucky
- Study coordinator: Morganti, Josh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.