Investigating the role of APOE genes in Alzheimer's disease risk and prevention
APOE in the Predisposition to, Protection from and Prevention of Alzheimer's Disease
This study is looking at how different versions of a gene called APOE might influence the chances of developing Alzheimer's disease in people aged 50 to 90 who are currently healthy, and it involves brain scans and blood tests to help researchers learn more about this connection over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Banner Health NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project ID | NIH-11086129 on NIH RePORTER |
What this research studies
This research focuses on understanding how different APOE genotypes affect the risk of developing Alzheimer's disease in cognitively unimpaired individuals aged 50 to 90. The study will create a cohort of 300 participants with various APOE genotypes, allowing researchers to collect and analyze genetic, clinical, and biomarker data over time. Participants will undergo brain imaging and provide samples for blood and cerebrospinal fluid analysis to track changes related to Alzheimer's pathology. The goal is to identify critical biomarkers and understand their relationship with age and genetic risk factors.
Who could benefit from this research
Good fit: Ideal candidates for this research are cognitively unimpaired individuals aged 50 to 90 with varying APOE genotypes.
Not a fit: Patients who are already diagnosed with Alzheimer's disease or those under 50 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing Alzheimer's disease in at-risk populations.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors influencing Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
Phoenix, United States
- Banner Health — Phoenix, United States (Active)
Researchers
- Principal investigator: Reiman, Eric Michael — Banner Health
- Study coordinator: Reiman, Eric Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.