Investigating the role of APOE genes in Alzheimer's disease risk and prevention
Official title: APOE in the Predisposition to, Protection from and Prevention of Alzheimer's Disease
Funded at Banner Health · NIH-11086129 · Data updated 2026-11-12
This study is looking at how different versions of a gene called APOE might influence the chances of developing Alzheimer's disease in people aged 50 to 90 who are currently healthy, and it involves brain scans and blood tests to help researchers learn more about this connection over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Banner Health NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | September 30, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $4,474,198 |
| NIH project number | 5R01AG069453-05 |
| Project ID | NIH-11086129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cognitively unimpaired individuals aged 50 to 90 with varying APOE genotypes.
✕Less likely to help
Patients who are already diagnosed with Alzheimer's disease or those under 50 years old may not benefit from this research.
What this research studies
This research focuses on understanding how different APOE genotypes affect the risk of developing Alzheimer's disease in cognitively unimpaired individuals aged 50 to 90. The study will create a cohort of 300 participants with various APOE genotypes, allowing researchers to collect and analyze genetic, clinical, and biomarker data over time. Participants will undergo brain imaging and provide samples for blood and cerebrospinal fluid analysis to track changes related to Alzheimer's pathology. The goal is to identify critical biomarkers and understand their relationship with age and genetic risk factors.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing Alzheimer's disease in at-risk populations.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors influencing Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
-
Banner Health
Phoenix, United States Active
Researchers
- Principal investigator: Reiman, Eric Michael — Banner Health
- Study coordinator: Reiman, Eric Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.