Investigating the role of apelin in preeclampsia during pregnancy
Endogenous Apelin Receptor Ligands and Early Stages of Preeclamptic Pregnancy
This study is looking at how certain molecules in the body might help prevent preeclampsia, a serious condition during pregnancy that causes high blood pressure, with the hope of finding new ways to keep moms and babies healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10832483 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular factors that contribute to preeclampsia, a serious pregnancy complication characterized by high blood pressure. The study explores the apelinergic system, which includes apelin and elabela, to determine how these molecules affect placentation and trophoblast function. By examining their actions on cellular signaling pathways, the research aims to identify potential therapeutic interventions that could improve outcomes for mothers and their babies. The ultimate goal is to develop strategies that reduce the incidence of preeclampsia and enhance cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals at risk of developing preeclampsia or those diagnosed with the condition.
Not a fit: Patients who are not pregnant or those with pre-existing cardiovascular conditions unrelated to pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for preeclampsia, improving maternal and fetal health outcomes.
How similar studies have performed: Previous research has shown promising results in targeting the apelinergic system for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Yamaleyeva, Liliya M — Wake Forest University Health Sciences
- Study coordinator: Yamaleyeva, Liliya M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.