Investigating the role of antibodies in obesity-related fat tissue changes
Official title: IgG and Adipose Pathological Remodeling
Funded at Columbia University Health Sciences · NIH-11049161 · Data updated 2026-11-12
This study is looking at how being overweight affects fat tissue and its role in health, especially regarding insulin resistance and type 2 diabetes, by testing how a specific protein called IgG influences inflammation and metabolism in mice, with hopes of finding new ways to help people with obesity-related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 6, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $435,767 |
| NIH project number | 5R01DK134471-03 |
| Project ID | NIH-11049161 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from obesity or related metabolic disorders, particularly those with insulin resistance or type 2 diabetes.
✕Less likely to help
Patients who are not overweight or do not have metabolic disorders may not benefit from this research.
What this research studies
This research explores how obesity affects adipose tissue, which is crucial for metabolic health. It focuses on the accumulation of immunoglobulin G (IgG) in fat tissues and how this impacts conditions like insulin resistance and type 2 diabetes. The study involves testing the effects of IgG on fat tissue inflammation and metabolic function in mice, with the goal of identifying potential therapeutic targets to improve metabolic health. By understanding these mechanisms, the research aims to develop new strategies for treating obesity-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity-related conditions such as type 2 diabetes and cardiovascular diseases.
How similar studies have gone: Other research has shown promising results in understanding the role of immune factors in obesity, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Ferrante, Anthony W — Columbia University Health Sciences
- Study coordinator: Ferrante, Anthony W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.