Investigating the role of antibodies in blood clotting and pregnancy complications
Official title: Thrombosis and Antiphospholipid Antibodies
Funded at Michael E Debakey VA Medical Center · NIH-11003261 · Data updated 2026-11-12
This study is looking at how certain antibodies in the blood might cause problems with blood clotting and pregnancy, especially during the middle of pregnancy, and it aims to find out how these antibodies affect the placenta and blood vessels, so we can better help patients who are dealing with these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michael E Debakey VA Medical Center NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX005939-02 |
| Project ID | NIH-11003261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant individuals with a history of midtrimester abortion or those diagnosed with antiphospholipid syndrome.
✕Less likely to help
Patients without a history of blood clotting disorders or pregnancy complications may not benefit from this research.
What this research studies
This research focuses on understanding how anticardiolipin antibodies, particularly those targeting β2-glycoprotein I, are linked to blood clotting issues and complications during pregnancy, such as midtrimester abortion. The study aims to uncover the mechanisms behind these antibodies and their effects on placental health and vascular function. By examining the relationship between these antibodies and mitochondrial function, the research seeks to provide insights into potential therapeutic targets for affected patients. Patients may be involved in providing samples or data to help elucidate these connections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients experiencing pregnancy complications related to blood clotting disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of antiphospholipid antibodies in thrombosis, indicating that this approach may yield valuable insights.
Where this research is happening
-
Michael E Debakey VA Medical Center
Houston, United States Active
Researchers
- Principal investigator: Thiagarajan, Perumal — Michael E Debakey VA Medical Center
- Study coordinator: Thiagarajan, Perumal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.