Investigating the role of ANT2 in inflammation and insulin resistance related to diabetes
ANT2 in metaflammation and insulin resistance
This study is looking at how a protein called ANT2 affects inflammation and insulin resistance, which are important in Type 2 diabetes, to find new ways to help improve insulin sensitivity for people living with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10992197 on NIH RePORTER |
What this research studies
This research focuses on understanding how a protein called ANT2 contributes to inflammation and insulin resistance, which are key factors in the development of Type 2 diabetes. The study aims to explore the mechanisms by which obesity-induced inflammation, known as metaflammation, affects insulin sensitivity. By examining the activity of immune cells called macrophages and their mitochondrial function, the research seeks to identify potential new therapeutic targets for improving insulin sensitivity in patients with diabetes. Patients may be involved in studies that assess the impact of these findings on diabetes management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Type 2 diabetes, particularly those experiencing insulin resistance and obesity.
Not a fit: Patients with Type 1 diabetes or those without insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and better control Type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in targeting inflammation to improve insulin sensitivity, suggesting that this approach may be effective.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Lee, Yun Sok — University of California, San Diego
- Study coordinator: Lee, Yun Sok
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.