Investigating the role of Ankyrin-B in brain development and function
Role of Ankyrin-B in the Nervous System
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10549822
This study is looking at a protein called Ankyrin-B to see how it helps brain cells connect and grow, which is important for mental health, especially in understanding conditions like autism and other psychiatric disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10549822 on ClinicalTrials.gov |
What this research studies
This research explores how Ankyrin-B, a protein crucial for the development and functioning of neurons, affects the connections in the brain. It examines the role of different forms of Ankyrin-B in axonal growth and synapse formation, which are vital for proper brain function. By studying both human and mouse models, the research aims to understand how mutations in the ANK2 gene, which encodes Ankyrin-B, may contribute to conditions like autism and other psychiatric disorders. The findings could lead to new insights into the biological mechanisms underlying these mental health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autism spectrum disorder or other psychiatric conditions linked to axonal development issues.
Not a fit: Patients with psychiatric disorders not associated with axonal development or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new targets for therapies aimed at treating neurodevelopmental and psychiatric disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of axonal transport in neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LORENZO, DAMARIS N — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: LORENZO, DAMARIS N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Mental health disorders, Psychiatric Disease, Psychiatric Disorder