Investigating the role of amyloid and tau in Alzheimer's disease and cognitive decline
CAA, Tau and Neurodegeneration
This study is looking at how certain brain changes related to Alzheimer's disease might affect memory and thinking, and it hopes to find ways to protect the brain and improve outcomes for people with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11290623 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between cerebral amyloid angiopathy (CAA), tau protein accumulation, and neurodegeneration in Alzheimer's disease. It aims to explore how CAA contributes to cognitive decline by examining the role of specific reactive astrocytes and the complement system in the disease process. The researchers will investigate whether reducing tau expression in these astrocytes can lead to neuroprotection and improved outcomes for patients. By identifying the molecular mechanisms involved, the study seeks to uncover potential therapeutic targets for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing age-related cognitive decline.
Not a fit: Patients with cognitive decline not related to Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent cognitive decline in Alzheimer's disease patients.
How similar studies have performed: Previous research has shown promising results in understanding the roles of amyloid and tau in neurodegeneration, suggesting that this approach could yield significant insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Lasagna-Reeves, Cristian — Baylor College of Medicine
- Study coordinator: Lasagna-Reeves, Cristian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.