Investigating the role of amylin protein in type 2 diabetes
Official title: Structural Investigation of Amylin Oligomers Associated to Type-2 Diabetes
Funded at Florida State University · NIH-11086829 · Data updated 2026-11-12
This study is looking at how a protein called amylin behaves in people with type 2 diabetes and how it might harm cells, with the goal of finding new ways to prevent these problems and improve treatments for diabetes-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | August 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $364,784 |
| NIH project number | 5R01DK132214-05 |
| Project ID | NIH-11086829 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes, particularly those experiencing complications related to the disease.
✕Less likely to help
Patients without type 2 diabetes or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research focuses on understanding how the amylin protein aggregates in type 2 diabetes and its connection to cell damage. By using advanced techniques like NMR spectroscopy, the study aims to identify the toxic forms of amylin and how they interact with metals like zinc and copper. The research will also explore how these interactions affect cell health and the potential for developing inhibitors to prevent amylin aggregation. Patients may benefit from insights that could lead to new treatments for diabetes-related complications.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating complications associated with type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding amyloid proteins and their role in diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Ramamoorthy, Ayyalusamy — Florida State University
- Study coordinator: Ramamoorthy, Ayyalusamy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.