Investigating the role of amphiregulin in oral immunity and inflammation during HIV infection
Amphiregulin-Immunometabolism axis in oral immunity and inflammation during HIV infection
This study is looking at how HIV affects the immune system in the mouth and how a protein called amphiregulin plays a role, with the goal of finding better ways to help people living with HIV manage oral health and inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11110306 on NIH RePORTER |
What this research studies
This research focuses on understanding how HIV infection affects oral immunity and inflammation, particularly through the role of a protein called amphiregulin. It examines the dysfunction of specific immune cells in the oral mucosa of people living with HIV and how this dysfunction contributes to systemic inflammation. The study will explore the impact of oral fungal imbalances on immune cell behavior and the underlying biological pathways involved. By analyzing these interactions, the research aims to identify new strategies for managing oral immune dysfunction in HIV patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who experience oral inflammation or related complications.
Not a fit: Patients who are not living with HIV or do not have oral inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management of oral health and systemic inflammation in individuals living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding immune dysfunction in HIV, making this approach a continuation of established findings.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Pandiyan, Pushpa — Case Western Reserve University
- Study coordinator: Pandiyan, Pushpa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.