Investigating the role of ameloblastin in children's tooth enamel health
Official title: Enamel with overexpressed ameloblastin
Funded at University of Texas Hlth Science Center · NIH-10920355 · Data updated 2026-11-12
This study is looking at how a protein called ameloblastin might be causing tooth problems in kids with Molar-Incisor Hypomineralization (MIH), which makes their teeth chalky and more prone to cavities, with the goal of finding better ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 5, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $349,370 |
| NIH project number | 5R01DE026769-07 |
| Project ID | NIH-10920355 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who exhibit signs of Molar-Incisor Hypomineralization.
✕Less likely to help
Patients who do not have Molar-Incisor Hypomineralization or related enamel defects may not benefit from this research.
What this research studies
This research focuses on Molar-Incisor Hypomineralization (MIH), a condition affecting children's teeth that leads to chalky, yellow lesions and increased susceptibility to cavities. The study aims to understand how overexpression of the enamel protein ameloblastin contributes to these enamel defects. By examining the pathways involved in enamel formation and degradation, the researchers hope to uncover the underlying mechanisms of MIH. This could lead to more effective treatments and management strategies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve enamel health and reduce dental issues in children with MIH.
How similar studies have gone: While the specific approach of investigating ameloblastin in MIH is novel, similar studies have shown promise in understanding enamel formation and related dental conditions.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Chun, Yong-Hee Patricia — University of Texas Hlth Science Center
- Study coordinator: Chun, Yong-Hee Patricia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.