Investigating the role of Adamts9 in female fertility and ovarian health
"To Survive or Die" - Adamts9 in Folliculogenesis and Germ Cell Loss
This study is looking at how a specific enzyme called Adamts9 affects the health and growth of ovarian follicles, which are important for female fertility, to help us better understand what keeps the ovaries functioning well.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | East Carolina University NIH-funded |
| Lab location | 1 site (Greenville, United States) |
| Project ID | NIH-10514260 on NIH RePORTER |
What this research studies
This research focuses on understanding how the Adamts9 enzyme influences the development and maintenance of ovarian follicles, which are crucial for female fertility. By examining the interactions and pathways involving Adamts9, the study aims to uncover the mechanisms that regulate ovarian health and the survival of follicles. The research employs various methodologies, including imaging techniques and assays to assess cell death and proliferation, to explore the role of this enzyme in ovarian function. The ultimate goal is to enhance knowledge about factors affecting female reproductive processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing fertility issues or those interested in understanding ovarian health.
Not a fit: Patients who are male or those not experiencing any fertility-related concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for female infertility.
How similar studies have performed: Previous research has shown promising results in understanding the role of similar enzymes in reproductive health, suggesting potential for success in this area.
Where this research is happening
Greenville, United States
- East Carolina University — Greenville, United States (Active)
Researchers
- Principal investigator: Zhu, Yong — East Carolina University
- Study coordinator: Zhu, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.