Investigating the role of a specific RNA in lung cancer progression
Deregulation of long noncoding RNAs in cancer
This study is looking at how a specific molecule called Malat1 affects the growth of lung cancer, and it's for people with lung adenocarcinoma who want to know more about potential new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10877863 on NIH RePORTER |
What this research studies
This research focuses on understanding how the long noncoding RNA (lncRNA) Malat1 contributes to the progression of lung adenocarcinoma (LUAD). By utilizing advanced CRISPR activation techniques, the study aims to model the effects of Malat1 overexpression in both patient-derived cell lines and mouse models. The researchers will explore how Malat1 influences tumor growth and the surrounding tumor microenvironment, potentially leading to more aggressive cancer behavior. This work could uncover new therapeutic targets for treating lung cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with lung adenocarcinoma who may benefit from novel therapeutic approaches.
Not a fit: Patients with other types of cancer or those without lung adenocarcinoma may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that specifically target the mechanisms driving lung cancer progression.
How similar studies have performed: Previous research has shown promising results in targeting long noncoding RNAs in cancer, suggesting that this approach could be effective.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Dimitrova, Nadya M — Yale University
- Study coordinator: Dimitrova, Nadya M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.