Investigating the role of a specific RNA in Alzheimer's disease and memory loss
Official title: The role of IncRNA Neat1 in Alzheimer's disease and related memory deficits
Funded at University of Alabama at Birmingham · NIH-11057618 · Data updated 2026-11-12
This study is looking at how a specific type of RNA, called Neat1, influences memory-related genes in the brain's hippocampus, especially in people with Alzheimer's disease, to find new ways to help improve memory and cognitive function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $643,968 |
| NIH project number | 5R01AG082089-03 |
| Project ID | NIH-11057618 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related memory disorders.
✕Less likely to help
Patients with other types of dementia not related to Alzheimer's may not benefit from this research.
What this research studies
This research explores how long non-coding RNAs, particularly Neat1, affect gene activity in the hippocampus, a brain area crucial for memory, in the context of Alzheimer's disease. The study aims to understand the disruptions in gene transcription caused by Alzheimer's and how these changes contribute to memory deficits. By examining the potential of lncRNAs to enhance memory resilience, the research seeks to identify new therapeutic strategies that could improve cognitive function in individuals affected by Alzheimer's. The approach includes detailed experiments using animal models to assess the impact of manipulating Neat1 expression on memory-related gene regulation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory function in patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of epigenetic factors in memory and Alzheimer's, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Lubin, Farah Dominique — University of Alabama at Birmingham
- Study coordinator: Lubin, Farah Dominique
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.