Investigating the role of a specific receptor in the visual cortex of ferrets
A genetic approach to elucidate the role of NMDA in the development and function of horizontal connections in ferret visual cortex
This study is exploring a new way to use a genetic tool to change certain genes in the brains of ferrets to learn more about how these changes affect their vision, which could help us understand similar processes in humans.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11068309 on NIH RePORTER |
What this research studies
This research focuses on using a genetic technique called iontoporation to deliver CRISPR/Cas9 into the visual cortex of ferrets. By manipulating the expression of certain genes, particularly those related to N-Methyl-D-aspartic acid receptors (NMDARs), the researchers aim to understand how these genes influence the development and function of visual circuitry. The ferret model is chosen due to its well-characterized visual development, allowing for insights that may be applicable to higher mammals, including humans. The study will involve both laboratory and live animal experiments to validate the effectiveness of this genetic manipulation.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals with conditions related to visual processing or brain pathologies such as schizophrenia.
Not a fit: Patients with conditions unrelated to visual processing or those who are not affected by brain pathologies may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new genetic models for understanding brain pathologies, potentially improving treatments for conditions like schizophrenia.
How similar studies have performed: While this approach is innovative, similar genetic manipulation techniques have shown promise in other animal models, suggesting potential for success in this novel application.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Scholl, Benjamin Kyle — University of Colorado Denver
- Study coordinator: Scholl, Benjamin Kyle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.