Investigating the role of a specific protein in treating osteoarthritis
Official title: Therapeutic role of NFAT1 Transcription Factor in Osteoarthritis
Funded at University of Kansas Medical Center · NIH-10781661 · Data updated 2026-11-12
This study is looking at how a protein called NFAT1 affects osteoarthritis in older adults, with the hope of finding new ways to slow down or even reverse the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $473,040 |
| NIH project number | 1R01AR083469-01 |
| Project ID | NIH-10781661 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of osteoarthritis.
✕Less likely to help
Patients with osteoarthritis who are under 21 years old or those with other joint diseases unrelated to osteoarthritis may not benefit from this research.
What this research studies
This research focuses on understanding how the NFAT1 transcription factor influences the development and progression of osteoarthritis (OA), a common joint disease affecting older adults. The study aims to explore the mechanisms by which NFAT1 levels in joint tissues relate to the severity of OA, particularly as they change with age. By using animal models and preliminary human studies, researchers will assess the potential of targeting NFAT1 to develop new therapies that could slow or reverse OA progression.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively halt or reverse the progression of osteoarthritis.
How similar studies have gone: Previous studies have shown promising results in targeting transcription factors for joint diseases, suggesting potential success for this approach.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Wang, Jinxi — University of Kansas Medical Center
- Study coordinator: Wang, Jinxi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.