Investigating the role of a specific protein in pulmonary hypertension
Official title: Hv1 in Pulmonary Hypertension
Funded at University of Illinois at Chicago · NIH-11133419 · Data updated 2026-11-12
This study is looking at how a protein called Hv1 affects high blood pressure in the lungs, and it aims to find new ways to treat this condition by testing different blockers in animals, which could lead to better options for patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | June 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $522,794 |
| NIH project number | 1R01HL174544-01A1 |
| Project ID | NIH-11133419 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary hypertension or those at risk for developing this condition.
✕Less likely to help
Patients with pulmonary hypertension caused by factors unrelated to the mechanisms being studied may not benefit from this research.
What this research studies
This research focuses on understanding how the Hv1 protein contributes to pulmonary hypertension, a condition characterized by high blood pressure in the lungs. The study will utilize animal models to explore the mechanisms by which Hv1 influences cell proliferation and apoptosis in the pulmonary vasculature. By examining the effects of Hv1 blockers, the research aims to uncover potential therapeutic targets for treating pulmonary hypertension. Patients may benefit from insights gained about the disease's underlying mechanisms and potential new treatment options.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage or treat pulmonary hypertension.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in other vascular disorders, suggesting potential for success in this area as well.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Hong, Liang — University of Illinois at Chicago
- Study coordinator: Hong, Liang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.