Investigating the role of a specific protein in ovarian cancer
Official title: Role of protein kinase ADCK5 in ovarian cancer
Funded at University of Maryland Baltimore County · NIH-10725728 · Data updated 2026-11-12
This study is looking at how a protein called ADCK5 affects the growth of ovarian cancer and why some treatments might not work, with the goal of finding better ways to help patients with ovarian cancer live longer and healthier lives.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore County NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $150,271 |
| NIH project number | 1R03CA282712-01 |
| Project ID | NIH-10725728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with ovarian cancer, especially those with p53 mutations.
✕Less likely to help
Patients with early-stage ovarian cancer or those without p53 mutations may not benefit from this research.
What this research studies
This research focuses on understanding how the protein kinase ADCK5 influences ovarian cancer progression and treatment resistance. By examining the genetic factors associated with ADCK5, researchers aim to identify new therapeutic targets that could improve treatment outcomes for patients with ovarian cancer. The study will analyze the relationship between ADCK5 expression and patient survival, particularly in those with specific genetic mutations. This could lead to more effective treatment strategies for patients facing this challenging disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve survival rates for ovarian cancer patients, particularly those with drug-resistant forms of the disease.
How similar studies have gone: Previous research has shown promising results in targeting genetic factors in cancer treatment, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
-
University of Maryland Baltimore County
Baltimore, United States Active
Researchers
- Principal investigator: Padmanabhan, Achuth — University of Maryland Baltimore County
- Study coordinator: Padmanabhan, Achuth
Related research
Other NIH-funded projects on the same topics.
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-
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-
Integrated framework to validate and quantify proteoforms in patient-derived ovarian cancer cells
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Overcoming platinum resistance in ovarian cancer: finding biomarkers and new targets
Researchers are looking for new biomarkers and targets to help prevent or overcome platinum resistance in high‑risk ovarian cancer so patients have better chances at long-term control.
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Alternative NF-kB activation after chemotherapy in ovarian cancer
This grant studies how ovarian cancer might come back after chemotherapy by looking at specific signaling pathways in cancer cells and the tumor environment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.