Investigating the role of a specific protein in memory loss and cognitive decline in Alzheimer's disease.
Neuronal HDAC9, Synaptic Plasticity and Alzheimer's Disease
This study is looking at how a protein called HDAC9 impacts memory and thinking skills in people with Alzheimer's disease, using animal models to see if changing HDAC9 levels can help improve brain health and cognitive abilities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11014416 on NIH RePORTER |
What this research studies
This research focuses on understanding how a protein called HDAC9 affects memory and cognitive function in Alzheimer's disease (AD), which is a condition that worsens with age. The researchers will explore how changes in HDAC9 levels in the brain relate to cognitive decline and synaptic dysfunction associated with aging and AD. They will use animal models to test their hypotheses and examine the effects of manipulating HDAC9 on cognitive abilities and brain health. The goal is to uncover potential therapeutic targets for improving memory and cognitive function in patients with AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients with early-stage cognitive impairment not related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance memory and cognitive function in individuals with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting similar epigenetic mechanisms for cognitive enhancement in neurodegenerative conditions.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Lu, Xin-Yun — Augusta University
- Study coordinator: Lu, Xin-Yun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.