Investigating the role of a specific protein in lung cancer development
Official title: Protein kinase C and lung carcinogenesis
Funded at University of Miami School of Medicine · NIH-11191507 · Data updated 2026-11-12
This study is looking at how a specific protein called PKCe affects lung cancer, especially in people with a certain gene change (KRAS mutations), to help find better ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $653,908 |
| NIH project number | 5R01CA276350-03 |
| Project ID | NIH-11191507 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with lung adenocarcinoma, especially those with KRAS mutations.
✕Less likely to help
Patients with lung cancer who do not have KRAS mutations may not benefit directly from the findings of this research.
What this research studies
This research focuses on understanding how the protein kinase C epsilon (PKCe) contributes to the development and progression of lung cancer, particularly in patients with KRAS mutations. By using genetically engineered mouse models, the researchers aim to explore the role of PKCe in both the initiation of lung tumors and their later stages, including metastasis. The study will involve examining how PKCe influences cancer cell behavior and signaling pathways, which could lead to new insights into lung cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting PKCe, potentially improving outcomes for lung cancer patients.
How similar studies have gone: Previous research has shown that targeting specific signaling pathways in cancer can lead to significant advancements in treatment, suggesting that this approach may also yield promising results.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Kazanietz, Marcelo G. — University of Miami School of Medicine
- Study coordinator: Kazanietz, Marcelo G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.