Investigating the role of a specific protein in liver injury related to bile duct diseases
Official title: Role of STING in Cholestatic Liver Injury
Funded at Texas A&m University Health Science Ctr · NIH-11085112 · Data updated 2026-11-12
This study is looking at how a protein called STING affects liver damage in people with primary sclerosing cholangitis (PSC) by examining the cells that line the bile ducts, which could help us find better ways to treat liver problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $470,085 |
| NIH project number | 5R01DK135881-03 |
| Project ID | NIH-11085112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with biliary liver diseases, particularly primary sclerosing cholangitis.
✕Less likely to help
Patients with liver diseases unrelated to cholestasis or those without a diagnosis of biliary liver conditions may not benefit from this research.
What this research studies
This research focuses on understanding how the STING protein contributes to liver damage in conditions like primary sclerosing cholangitis (PSC). By examining the behavior of cholangiocytes, which are cells lining the bile ducts, the study aims to uncover the mechanisms behind liver inflammation and fibrosis. The researchers will explore how STING is activated in response to certain cellular signals and how this activation affects liver health. The findings could lead to new insights into treating cholestatic liver diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients suffering from cholestatic liver diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of STING in liver inflammation, indicating that this approach has potential for success.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Glaser, Shannon Stroud — Texas A&m University Health Science Ctr
- Study coordinator: Glaser, Shannon Stroud
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.