Investigating the role of a specific protein in immune cell function
Official title: Creation and Characterization of Lineage-Restricted Stat5B KO Mice
Funded at Virginia Commonwealth University · NIH-11116916 · Data updated 2026-11-12
This study is looking at how a protein called Stat5B influences immune cells, especially those involved in allergies and inflammation, by using specially designed mice to see how different versions of this protein work, which could help us understand diseases related to immune problems.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | June 14, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $72,702 |
| NIH project number | 5R03AI182614-02 |
| Project ID | NIH-11116916 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from allergic diseases, autoimmune disorders, or related conditions impacted by immune system dysfunction.
✕Less likely to help
Patients with conditions unrelated to immune system dysfunction or those not experiencing allergic reactions may not benefit from this research.
What this research studies
This research focuses on understanding how a protein called Stat5B affects the function of immune cells, particularly mast cells, which play a crucial role in allergic reactions and inflammation. By creating special mice that lack this protein or have a modified version of it, researchers aim to explore the distinct roles of different forms of Stat5B in immune responses. This could lead to insights into various diseases linked to immune dysfunction, such as allergies, cancer, and autoimmune disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for allergic diseases and other conditions related to immune system dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the roles of similar proteins in immune function, indicating that this approach has potential for success.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Ryan, John J — Virginia Commonwealth University
- Study coordinator: Ryan, John J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.