Investigating the role of a specific protein in immune cell function
Creation and Characterization of Lineage-Restricted Stat5B KO Mice
['FUNDING_R03'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-11116916
This study is looking at how a protein called Stat5B influences immune cells, especially those involved in allergies and inflammation, by using specially designed mice to see how different versions of this protein work, which could help us understand diseases related to immune problems.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-11116916 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a protein called Stat5B affects the function of immune cells, particularly mast cells, which play a crucial role in allergic reactions and inflammation. By creating special mice that lack this protein or have a modified version of it, researchers aim to explore the distinct roles of different forms of Stat5B in immune responses. This could lead to insights into various diseases linked to immune dysfunction, such as allergies, cancer, and autoimmune disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from allergic diseases, autoimmune disorders, or related conditions impacted by immune system dysfunction.
Not a fit: Patients with conditions unrelated to immune system dysfunction or those not experiencing allergic reactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for allergic diseases and other conditions related to immune system dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding the roles of similar proteins in immune function, indicating that this approach has potential for success.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RYAN, JOHN J — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: RYAN, JOHN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease