Investigating the role of a specific protein in heart failure
Defining the Role of ROR2 in Right Ventricular Failure Pathogenesis
This study is looking at how a protein called ROR2 affects right ventricular failure, a serious heart problem, to help find new treatments, and it's being led by Dr. Jonathan Edwards, who is also learning new skills to improve his research.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10889095 on NIH RePORTER |
What this research studies
This research focuses on understanding how the ROR2 protein contributes to right ventricular failure (RVF), a serious heart condition. The principal investigator, Dr. Jonathan Edwards, will use advanced techniques in molecular biology and cardiomyocyte biology to explore the mechanisms behind RVF. By studying both human samples and mouse models, the research aims to identify potential therapeutic targets that could lead to new treatments for RVF. The project also includes training and development for Dr. Edwards to enhance his skills as a physician-scientist.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with right ventricular failure or those at high risk for developing this condition.
Not a fit: Patients with left ventricular failure or other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies for patients suffering from right ventricular failure.
How similar studies have performed: While the specific approach of targeting ROR2 in RVF is novel, similar research has shown promise in identifying molecular drivers of heart failure.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Edwards, Jonathan Joseph — Children's Hosp of Philadelphia
- Study coordinator: Edwards, Jonathan Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.