Investigating the role of a specific protein in early-onset endometrial cancer linked to obesity
PAI-1-mediated early-onset endometrial cancer
This study is looking at how being overweight might lead to endometrial cancer in younger women by exploring how certain cells and a protein affect communication in the uterus, with the hope of finding new ways to help manage this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11071968 on NIH RePORTER |
What this research studies
This research focuses on understanding how obesity contributes to early-onset endometrial cancer, particularly in younger patients. It examines the role of adipose stromal cells and a protein called plasminogen activator inhibitor-1 (PAI-1) in altering cellular communication within the endometrial tissue. By using advanced techniques like single-cell transcriptomic profiling, the study aims to uncover how PAI-1 affects the behavior of endometrial cells, potentially leading to cancer development. The findings could provide insights into new therapeutic strategies for managing this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are younger women diagnosed with endometrial cancer, particularly those with obesity-related factors.
Not a fit: Patients who are not diagnosed with endometrial cancer or those without obesity-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better management strategies for patients with early-onset endometrial cancer.
How similar studies have performed: Other research has shown promising results in understanding the role of adipokines in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Kirma, Nameer — University of Texas Hlth Science Center
- Study coordinator: Kirma, Nameer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.