Investigating the role of a specific protein in brain inflammation and Alzheimer's disease as we age.
Official title: Role of ADAR1 and dsRNA in age-related neuroinflammation and Alzheimers disease
Funded at Colorado State University · NIH-10933422 · Data updated 2026-11-12
This study is looking at how a protein called ADAR1 affects brain inflammation, especially in people with Alzheimer's disease and as we age, to see if lower levels of this protein might lead to harmful buildup in the brain, which could help us find new ways to treat Alzheimer's and reduce inflammation.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | August 17, 2023 |
| Project end | July 16, 2026 |
| Funding year | 2024 |
| Award (this year) | $41,627 |
| NIH project number | 5F31AG084330-02 |
| Project ID | NIH-10933422 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who are at risk for or currently experiencing symptoms of Alzheimer's disease.
✕Less likely to help
Patients with early-onset Alzheimer's disease or those without any signs of cognitive decline may not benefit from this research.
What this research studies
This research focuses on understanding how a protein called ADAR1 affects inflammation in the brain, particularly in the context of Alzheimer's disease and aging. The researcher, Cali McEntee, will explore whether lower levels of ADAR1 lead to the buildup of harmful molecules that trigger inflammation. By using various models, the study aims to uncover the relationship between ADAR1, neuroinflammation, and the aging process, which could provide insights into potential therapeutic targets for Alzheimer's disease. Patients may benefit from findings that could lead to new treatments aimed at reducing inflammation in the brain.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting neuroinflammation.
How similar studies have gone: Previous research has shown promising results in targeting neuroinflammation for Alzheimer's treatment, suggesting that this approach may be viable.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Mcentee, Cali Madison — Colorado State University
- Study coordinator: Mcentee, Cali Madison
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.