Investigating the role of a specific protein in blood cancers
Official title: The Role of PPM1D in Myeloproliferative Neoplasms
Funded at Icahn School of Medicine at Mount Sinai · NIH-11032827 · Data updated 2026-11-12
This study is looking at how a protein called PPM1D affects the progression of chronic blood disorders known as Myeloproliferative Neoplasms (MPNs) in patients with certain genetic changes, with the hope of finding new treatment options.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 20, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $164,404 |
| NIH project number | 5K08HL163489-03 |
| Project ID | NIH-11032827 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Myeloproliferative Neoplasms, particularly those with mutations in the JAK2 gene.
✕Less likely to help
Patients with other types of blood disorders or those without Myeloproliferative Neoplasms may not benefit from this research.
What this research studies
This research focuses on Myeloproliferative Neoplasms (MPNs), which are chronic blood disorders that can lead to severe health complications. The study aims to understand how the protein PPM1D contributes to the progression of these diseases, particularly in patients with specific genetic mutations. By using patient samples and advanced laboratory techniques, the researchers will explore how PPM1D affects blood cell development and disease progression, potentially leading to new treatment options.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively alter the course of Myeloproliferative Neoplasms and improve patient outcomes.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in blood cancers, indicating potential for success in this approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Marcellino, Bridget Kelly — Icahn School of Medicine at Mount Sinai
- Study coordinator: Marcellino, Bridget Kelly
Related research
Other NIH-funded projects on the same topics.
-
Biomarker clues to catch pancreatic cancer early in cysts
A study from UC San Diego is testing blood and cyst-fluid markers to help tell high-risk pancreatic cysts from low-risk ones so that people with pancreatic cysts can get the right care sooner.
-
Myeloproliferative Neoplasm Research Consortium
A large research collaboration across multiple centers aims to improve survival for patients with myelofibrosis and related myeloproliferative neoplasms through coordinated laboratory, translational, and clinical work.
-
Understanding how different CALR mutations drive certain blood cancers
This grant explores how two CALR mutation types cause myeloproliferative neoplasms and could lead to better treatments for people with these blood cancers.
-
Cell Competition in Myeloproliferative Neoplasms
This NIH grant explores how healthy and mutant blood stem cells interact in certain blood cancers to understand why some patients progress and how future therapies might help.
-
Targeting ERK’s brake pedals to slow cancer progression
Aims to block the parts of ERK signaling that speed up cancer progression, by guiding drugs to the substrate-binding domains that act like accelerator pedals in myeloproliferative neoplasms and related cancers.
-
Biomarker work to predict pancreatic IPMN cancer risk
A Duke University researcher is testing biomarkers to tell which pancreatic IPMN cysts are likely to become invasive cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.