Investigating the role of a specific protein in blood cancers
The Role of PPM1D in Myeloproliferative Neoplasms
This study is looking at how a protein called PPM1D affects the progression of chronic blood disorders known as Myeloproliferative Neoplasms (MPNs) in patients with certain genetic changes, with the hope of finding new treatment options.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11032827 on NIH RePORTER |
What this research studies
This research focuses on Myeloproliferative Neoplasms (MPNs), which are chronic blood disorders that can lead to severe health complications. The study aims to understand how the protein PPM1D contributes to the progression of these diseases, particularly in patients with specific genetic mutations. By using patient samples and advanced laboratory techniques, the researchers will explore how PPM1D affects blood cell development and disease progression, potentially leading to new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Myeloproliferative Neoplasms, particularly those with mutations in the JAK2 gene.
Not a fit: Patients with other types of blood disorders or those without Myeloproliferative Neoplasms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively alter the course of Myeloproliferative Neoplasms and improve patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in blood cancers, indicating potential for success in this approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Marcellino, Bridget Kelly — Icahn School of Medicine at Mount Sinai
- Study coordinator: Marcellino, Bridget Kelly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.