Investigating the role of a specific protein in Alzheimer's disease
Official title: Role of KDM6B in Alzheimer’s disease related dementia
Funded at Ut Southwestern Medical Center · NIH-11075907 · Data updated 2026-11-12
This study is looking at how a protein called KDM6B impacts brain function in people with Alzheimer's disease, with the goal of finding new ways to help improve memory and thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $734,517 |
| NIH project number | 5R01AG079094-03 |
| Project ID | NIH-11075907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing cognitive decline.
✕Less likely to help
Patients with early-stage Alzheimer's disease who do not exhibit significant cognitive impairment may not benefit from this research.
What this research studies
This research focuses on understanding how the protein KDM6B affects brain function in Alzheimer's disease, which is a major cause of dementia. The study aims to uncover the mechanisms behind changes in brain activity and neurotransmitter levels that contribute to cognitive decline in patients. By examining the role of KDM6B in regulating synaptic plasticity and memory, the researchers hope to identify potential targets for new treatments. The approach includes using animal models to observe the effects of KDM6B on brain function and behavior.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and improving cognitive function in affected patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of epigenetic factors in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Wang, Yingfei — Ut Southwestern Medical Center
- Study coordinator: Wang, Yingfei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.