Investigating the role of a specific protein in Alzheimer's disease
The role of CELF2 and its genetic variants in Alzheimer's disease
This study is looking at how a protein called CELF2 and its genetic changes might affect the risk of developing Alzheimer's disease, and it aims to help us understand more about the condition and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11011320 on NIH RePORTER |
What this research studies
This research focuses on understanding how the CELF2 protein and its genetic variations influence the risk of developing Alzheimer's disease. By studying the effects of CELF2 on RNA splicing and stability, researchers aim to uncover its role in the pathology of Alzheimer's. The study involves using advanced techniques like CLIP-seq to identify how CELF2 interacts with genes related to Alzheimer's, and it includes experiments with genetically modified mice to observe the effects of CELF2 deletion on learning and memory. Patients may benefit from insights gained about genetic risk factors and potential therapeutic targets for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who may have a genetic predisposition to Alzheimer's disease.
Not a fit: Patients without a genetic risk for Alzheimer's or those who are not adults may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting genetic risk factors.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Chen, Lizhen — University of Texas Hlth Science Center
- Study coordinator: Chen, Lizhen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.