Investigating the role of a specific protein channel in Alzheimer's disease
Structural and functional characterization of ATP synthase c-subunit leak channel and its role in AD pathogenesis
This study is looking at a specific protein channel that might play a role in Alzheimer's disease, and it's for anyone interested in understanding how this channel works, especially when it interacts with a protein linked to the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11081812 on NIH RePORTER |
What this research studies
This research focuses on understanding how a protein channel, known as the ATP synthase c-subunit leak channel, contributes to the development of Alzheimer's disease. By using advanced imaging techniques like cryo-electron microscopy, researchers aim to uncover the structure and function of this channel, particularly how it behaves in the presence of amyloid-beta, a key protein involved in Alzheimer's. The study will analyze both isolated mitochondria and neurons affected by Alzheimer's to gain insights into the underlying mechanisms of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting mitochondrial dysfunction in Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in Alzheimer's, but the specific approach of targeting the ATP synthase c-subunit is relatively novel.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Mnatsakanyan, Nelli — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Mnatsakanyan, Nelli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.