Investigating the role of a specific microRNA in lung disease-related high blood pressure
Official title: Role of miR125 in pulmonary hypertension secondary to interstitial lung disease
Funded at University of California Los Angeles · NIH-10524037 · Data updated 2026-11-12
This study is looking at how a tiny molecule called miR125b affects high blood pressure in the lungs caused by lung diseases like pulmonary fibrosis, using a rat model to find new ways to help treat this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | December 1, 2019 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $474,894 |
| NIH project number | 5R01HL147586-04 |
| Project ID | NIH-10524037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary fibrosis who are experiencing pulmonary hypertension.
✕Less likely to help
Patients with pulmonary hypertension not related to interstitial lung disease may not benefit from this research.
What this research studies
This research focuses on understanding how a microRNA called miR125b contributes to pulmonary hypertension (PH) that occurs as a complication of interstitial lung disease, particularly pulmonary fibrosis. The researchers have developed a rat model that mimics the disease in humans, allowing them to study the mechanisms by which miR125b promotes changes in lung blood vessels and contributes to increased blood pressure in the lungs. By examining the effects of miR125b on lung cells, the study aims to uncover potential new therapeutic targets for treating this serious condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients suffering from pulmonary hypertension related to interstitial lung disease.
How similar studies have gone: While the specific approach of targeting miR125b in this context is novel, similar research has shown promise in understanding the role of microRNAs in other diseases.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Eghbali, Mansoureh — University of California Los Angeles
- Study coordinator: Eghbali, Mansoureh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.