Investigating the role of a specific microRNA in Alzheimer's disease
MicroRNA Mouse Models and Alzheimer’s Disease
This study is looking at how a tiny molecule called microRNA-455-3p might influence the progression of Alzheimer's disease, using mice to learn more about its effects on brain health, and it could help find new ways to treat or manage the condition for people living with Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-10526166 on NIH RePORTER |
What this research studies
This research focuses on understanding how microRNA-455-3p affects Alzheimer's disease progression. By studying mouse models, the researchers aim to uncover the mechanisms by which this microRNA influences amyloid-β production and clearance, synaptic damage, and neuronal loss. The approach includes analyzing changes in microRNA levels in both brain tissues and peripheral systems of individuals with varying stages of Alzheimer's. The findings could provide insights into potential therapeutic targets for managing or treating Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those experiencing mild cognitive impairment.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing or treating Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding microRNA roles in neurodegenerative diseases, suggesting potential for success in this approach.
Where this research is happening
Lubbock, United States
- Texas Tech University Health Scis Center — Lubbock, United States (Active)
Researchers
- Principal investigator: Reddy, P. Hemachandra — Texas Tech University Health Scis Center
- Study coordinator: Reddy, P. Hemachandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.