Investigating the role of a specific microRNA in allergic asthma
Functional role of miR-511-3p in allergic asthma and its underlying mechanisms
This study is looking at how a tiny molecule called miR-511-3p affects allergic asthma, especially when triggered by cockroach allergens, to find new ways to help people with this condition breathe easier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11065419 on NIH RePORTER |
What this research studies
This research focuses on understanding how a microRNA called miR-511-3p influences allergic asthma, particularly in response to cockroach allergens. The team aims to uncover the molecular mechanisms behind allergic sensitization and inflammation in the airways. By studying how this microRNA interacts with immune cells, specifically macrophages, the research seeks to identify new therapeutic targets that could improve treatment for patients with allergic asthma. The approach includes profiling immune responses and examining the signaling pathways involved in allergic reactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with allergic asthma, particularly those sensitized to cockroach allergens.
Not a fit: Patients without allergic asthma or those not sensitized to cockroach allergens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent allergic asthma triggered by common allergens.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in allergic responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Gao, Peisong — Johns Hopkins University
- Study coordinator: Gao, Peisong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.