Investigating the role of a specific microRNA in abdominal aortic aneurysm
Role of miR-146a in Abdominal Aortic Aneurysm
This study is looking at how a tiny molecule called microRNA-146a affects the health of the abdominal aorta, especially for people at risk of abdominal aortic aneurysms, to see if it could help create new non-surgical treatments to keep their aorta strong and prevent serious problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11001154 on NIH RePORTER |
What this research studies
This research focuses on understanding how microRNA-146a influences the health of the abdominal aorta, particularly in the context of abdominal aortic aneurysms (AAA). The study aims to explore the mechanisms by which this microRNA affects vascular smooth muscle cells, which are crucial for maintaining the aorta's structure and function. By using advanced techniques such as RNA sequencing and in-situ hybridization, researchers will investigate the potential of miR-146a as a therapeutic target to prevent the progression and rupture of AAAs. This could lead to the development of new non-surgical treatment options for patients at risk of AAA.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with abdominal aortic aneurysms or those at high risk for developing them.
Not a fit: Patients without abdominal aortic aneurysms or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly reduce the risk of abdominal aortic aneurysm progression and rupture.
How similar studies have performed: Previous research has shown promising results in targeting microRNAs for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Subramanian, Venkateswaran — University of Missouri-Columbia
- Study coordinator: Subramanian, Venkateswaran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.