Investigating the role of a specific hormone in childhood hypertension and its effects on heart and kidney health
The role of angiotensin-(1-7) in hypertension and hypertension-induced heart and kidney damage
This study is looking at how a substance called angiotensin-(1-7) affects high blood pressure in kids aged 5 to 17, to find out why some don’t respond well to treatments, with the hope of creating better ways to help manage their blood pressure and protect their hearts and kidneys.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10868656 on NIH RePORTER |
What this research studies
This research focuses on understanding how angiotensin-(1-7) influences hypertension in children aged 5 to 17 years. It aims to identify why some children do not respond well to hypertension treatments, which can lead to heart and kidney damage. By measuring levels of angiotensin-(1-7), uric acid, and klotho in blood and urine, the study will analyze their relationships to blood pressure and organ health. The findings could help develop better treatment strategies for managing hypertension in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 5 to 17 years who have been diagnosed with hypertension.
Not a fit: Patients who do not have hypertension or are outside the age range of 5 to 17 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for childhood hypertension, reducing the risk of long-term heart and kidney damage.
How similar studies have performed: While research on angiotensin-(1-7) in adult hypertension exists, this specific focus on pediatric hypertension is novel and has not been extensively studied.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: South, Andrew Michael — Wake Forest University Health Sciences
- Study coordinator: South, Andrew Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.