Investigating the role of a specific genetic element in lupus
Role of the L1 retrotransposon in interferon-positive SLE
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11058353
This study is looking at how a specific part of our DNA, called L1, might play a role in lupus, a tricky autoimmune disease, to help find better treatments for people living with it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11058353 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the Long Interspersed Nuclear Element-1 (L1) contributes to systemic lupus erythematosus (SLE), a complex autoimmune disease. By examining the relationship between L1 and type I interferon in SLE patients, the study aims to identify molecular mechanisms that drive the disease. Researchers will analyze the expression of L1 in various immune cells and correlate it with disease activity and specific autoantibodies. This approach could lead to the development of targeted therapies that improve treatment outcomes for patients with SLE.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those exhibiting high levels of type I interferon activity.
Not a fit: Patients without a diagnosis of systemic lupus erythematosus or those with other autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target the underlying causes of lupus while minimizing effects on the overall immune system.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic elements in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUSTELIN, TOMAS M — UNIVERSITY OF WASHINGTON
- Study coordinator: MUSTELIN, TOMAS M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus