Investigating the role of a specific gene variant in brain function and its link to bipolar disorder
Oligodendroglial isoforms of ANK3 and their role in CNS function
This study is looking at how a specific gene called ANK3 might affect conditions like bipolar disorder, using mice to see if a special version of this gene can help protect against the illness and improve our understanding of the genetics behind mental health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10737608 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic variations in the ANK3 gene, particularly in oligodendrocytes, may influence neuropsychiatric disorders like bipolar disorder. By using advanced mouse models, researchers will explore the function of a unique splice variant of the ANK3 gene, known as BDex, and its potential protective effects against bipolar disease. The study will assess the structure and function of myelinated axons and the behavior of these mice to uncover the underlying mechanisms of these disorders. This research aims to provide insights into the genetic factors contributing to complex mental health conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of bipolar disorder or those diagnosed with the condition, particularly adolescents and adults.
Not a fit: Patients with neuropsychiatric disorders not linked to genetic factors or those without a family history of bipolar disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new genetic insights and potential therapeutic targets for treating bipolar disorder and related conditions.
How similar studies have performed: Previous research has shown promising results in understanding genetic contributions to neuropsychiatric disorders, indicating that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Rasband, Matthew N — Baylor College of Medicine
- Study coordinator: Rasband, Matthew N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.